Evidence map›Paper›PMID 41089938›Full record

ArticleJournal of family medicine and primary care2025

Beyond anticholinergic effects: A case of trihexyphenidyl-induced bradycardia.

Soumi Kundu, R G Medhagopal, Sarthak Das, Saroj K Tripathy, Sarbari Sarkar, Md E Ansari, Archana Malik

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Soumi KunduDepartment of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.
R G MedhagopalPG 1st Year Student, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.
Sarthak DasDepartment of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.
Saroj K TripathyDepartment of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.
Sarbari SarkarPG 1st Year Student, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.
Md E AnsariDepartment of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.
Archana MalikDepartment of Pulmonary Medicine, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anticholinergic drugs are extensively employed in clinical settings, with their side effects well-documented. However, paradoxical bradycardia due to trihexyphenidyl hydrochloride, an anticholinergic agent, is an infrequent and underreported phenomenon. This may be attributed to a lack of vigilant monitoring in patients undergoing therapy. Here, we present the case of a 12-year-old girl who developed sinus bradycardia following the administration of trihexyphenidyl. The heart rate normalized upon drug discontinuation. This report emphasizes the need for thorough cardiac monitoring, including baseline heart rate, Electrocardiogram (ECG), and electrolyte evaluation, before initiating therapy to prevent adverse outcomes.

Indexed as

Adverse drug reactionparadoxical bradycardiatrihexyphenidyl hydrochloride

Identifiers

PMID41089938
PMCPMC12517587

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.