ArticleJournal of spine surgery (Hong Kong)2025
Vascular anatomy of L1 vertebral body in Wistar rat-corrosion-fluorescence, diaphanization and histological analysis, comparison to humans, and importance in blood supply-related investigation.
Article in Journal of spine surgery (Hong Kong), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Anatomical and biological reconstruction of traumatic complete burst fractures of the thoracolumbar vertebrae using pedicle fixation combined with stent-armed kyphoplasty and intracorporeal bone grafting: technique rationale, 7-year experience and clinical, imaging, and histological outcomes.Journal of spine surgery (Hong Kong) · 2026Article
- Microvascular anatomy and mapping of intraosseous arterioles in the human L1 vertebral body: a histological study, literature comparison, and relevance for fracture healing.Journal of spine surgery (Hong Kong) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The factors influencing bone healing in complete burst fractures-key to deciding between stabilization or vertebral replacement-remain poorly defined. Arterial vascularization and bone nutrition are known to affect healing or progression to necrosis. However, the role of vascular injury in vertebral fractures is not yet conclusively demonstrated and is not currently factored into the decision-making for ad initium vertebral body replacement surgery. This study aims to analyze the vascularization of the L1 vertebral body in Wistar rats and compare it to human anatomy. The goal is to evaluate the suitability of the Wistar rat as a model for studying vertebral blood supply. Methods: Forty-three female Wistar rats (3 months old, 250-350 g) were used. After intraventricular injection of acrylic resin, three specimens underwent vascular corrosion-fluorescence. Twenty rats received latex injections and were converted into modified Spalteholz-cleared specimens. The remaining 20 underwent histological analysis of axial slices at upper, intermediate, and lower vertebral body levels. Cell nuclei of vascular endothelium, bone, cartilage, and marrow components were identified and analyzed by quadrant and central/peripheral distribution. Results: Several vascular structures observed macroscopically matched human anatomy, including: lumbar segmental arteries (100%), horizontal metaphyseal anastomoses (Hma) (56.52%), vertical anastomoses between adjacent vertebrae (34.78%), primary periosteal arteries (Ppa) (60.87%), anterior spinal canal branch (Ascb) of the lumbar artery (69.57%), its ascending and descending branches (52.17%), posterior intervertebral anastomoses (17.39%), posterior nutritive artery origins (47.83%), medial spinal branches (86.96%) and radicular branches (Rbs) (65.22%). Histologically, the vascular density averaged 101.09 endothelial nuclei per mm Conclusions: The vascular architecture of the L1 vertebral body in Wistar rats shows strong similarity to that of humans. These findings support the Wistar rat as a valid model for future studies on vertebral body vascularization and the role of ischemia in fracture healing and related pathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.