ArticleJournal of spine surgery (Hong Kong)2025
The healing process of vertebral body fracture in Wistar rats: creation of an animal model and demonstration of the impact of anterolateral vascularization disruption on bone healing.
Article in Journal of spine surgery (Hong Kong), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Anatomical and biological reconstruction of traumatic complete burst fractures of the thoracolumbar vertebrae using pedicle fixation combined with stent-armed kyphoplasty and intracorporeal bone grafting: technique rationale, 7-year experience and clinical, imaging, and histological outcomes.Journal of spine surgery (Hong Kong) · 2026Article
- Effects of azelnidipine, a calcium channel blocker, in a rat femur fracture model.BMC musculoskeletal disorders · 2026Article
- Microvascular anatomy and mapping of intraosseous arterioles in the human L1 vertebral body: a histological study, literature comparison, and relevance for fracture healing.Journal of spine surgery (Hong Kong) · 2026Article
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7 authors.
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Abstract
Background: Although recognition of avascular necrosis of the vertebral body in post-traumatic cases has increased, it remains underdiagnosed and is one of the most unpredictable and challenging complications in spinal trauma. Vertebral arterial supply may play a key role in fracture healing, yet this remains unproven and is not currently considered in treatment algorithms. Surgical decisions between preserving or replacing the vertebral body in burst fractures are difficult, mainly due to limited knowledge of the biological factors influencing bone repair. This study aims to demonstrate the impact of vertebral vascular disruption on vertebral body fracture healing. We developed an experimental model in Wistar rats to replicate an L1 vertebral body fracture and analyze the normal healing sequence. Additionally, we examined the effects of disrupting the anterolateral blood supply on bone regeneration. Methods: Seventy female Wistar rats were divided into two groups. Group 1 (n=35) underwent an L1 burst fracture induced by ultrasonic tools. Group 2 (n=35) received the same fracture, followed by electrocauterization of the anterolateral vertebral surfaces and placement of a synthetic barrier to prevent revascularization. Vertebral specimens were collected weekly for 6 weeks. Healing was assessed macroscopically and histologically using an image-processing algorithm trained to identify inflammatory, fibroblastic/cartilaginous, and bone tissue. The predominant tissue type was used to determine the healing stage. Results: At week 1, the vascular disruption group showed significantly more inflammatory tissue (56.34%) than controls (24.25%, P=0.03), while fibroblastic/cartilaginous tissue was more common in controls (58.82% Conclusions: Disruption of the anterolateral vascular supply significantly delays healing in L1 vertebral body fractures in rats, evidenced by slower phase transitions and reduced bone maturation. These findings underscore the essential role of vascularization in successful vertebral repair and suggest it should be considered in future therapeutic strategies.
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