SynthesisFrontiers in dental medicine2025
Salivary biomarkers for the prognosis of oncological and infectious diseases: a systematic review.
Synthesis in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Ru-N coordination hydrogen-bonded organic frameworks with enhanced peroxidase-like activity for colorimetric determination of gastric cancer-related salivary D-amino acids.Mikrochimica acta · 2026Article
- Altered Salivary Microbiome and Increased Immune Markers in Mouth-Breathing Children: Implications for Oral Health.International dental journal · 2026Article
- Relationships Between Salivary Biomarkers and Oral Function in Elderly People Using a Saliva Testing Device.Dentistry journal · 2026Article
- The Predictive Value of Clinical and Systemic Inflammatory Biomarkers in Emergency Colic Cancer Surgery: A Retrospective Study.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine the salivary biomarkers that are used in the prognosis of oncological and infectious diseases. Materials and methods: A bibliographic search was carried out until July 2025, in the biomedical databases: PubMed, Cochrane Library, Scopus, EMBASE, Web of Science (WoS), Scielo, Science Direct and Google Scholar. Studies that were clinical trials, which reported the use of salivary biomarkers for the prognosis of oncological and infectious diseases, without time and language limits, were included. The Cochrane Handbook of Systematic Reviews of Interventions was used to assess the risk of bias of the included studies. Results: The preliminary search yielded a total of 189 articles, discarding those that did not meet the selection criteria, leaving only 16 articles for qualitative synthesis. These studies reported that the most widely used salivary biomarkers in the prognosis of oncological and infectious diseases are cortisol and interleukins. Conclusions: Salivary biomarkers, especially cortisol and key interleukins, demonstrate potential as non-invasive tools for the prognostic assessment and monitoring of oncological and infectious diseases. Further standardization and clinical validation are needed to support their integration into routine practice. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42021260764, PROSPERO CRD42021260764.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.