ArticleFrontiers in pharmacology2025
The safety and efficacy of long-term use of calcitonin analogs in the treatment of osteoporosis in the elderly: a pharmacovigilance and RCT meta-analysis.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Combined Nanoparticle-Based Delivery of Estrogens and Raloxifen in Postmenopausal Osteoporosis.Nanomaterials (Basel, Switzerland) · 2026Review
- L-Quebrachitol Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption in Ovariectomized Rat Model.Biomolecules · 2026Article
- Modern Strategies for Osteoporosis Therapy: Current Status and Prospects for Targeted Intervention.International journal of molecular sciences · 2025Review
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Authors and funding
3 authors.
Funding
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Abstract
Background: Osteoporosis is a common metabolic bone disease in the elderly, and its incidence continues to rise with the global aging population. Calcitonin analogs (including synthetic salmon, human, and porcine calcitonin preparations) are a classic treatment option for osteoporosis; however, the safety and efficacy of their long-term use remain controversial despite widespread application. Objective: This study aims to systematically assess the safety and efficacy of long-term use of calcitonin analogs in the treatment of osteoporosis in the elderly through pharmacovigilance analysis and meta-analysis. Methods: The study evaluated the long-term effectiveness and adverse effects of calcitonin analogs using pharmacovigilance data from the FAERS database and a meta-analysis of randomized controlled trials (RCTs). The pharmacovigilance analysis included adverse event data from osteoporosis patients aged 65 and older from 2004 to 2023, and signal detection was performed using the reporting odds ratio (ROR), proportional reporting ratio (PRR), and Bayesian confidence propagation neural network (BCPNN) methods. The meta-analysis included RCT studies related to calcitonin published after 2010, and a random-effects model was used to calculate the hazard ratio (HR) with a 95% confidence interval. Results: Pharmacovigilance analysis revealed that nasal discomfort (ROR = 283.4, PRR = 264.5, IC = 7.3, IC Conclusion: Long-term use of calcitonin analogs for the treatment of osteoporosis in the elderly does not confer additional benefits and instead increases the risk of adverse reactions.
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