Evidence map›Paper›PMID 41089834›Full record

ArticleFrontiers in pharmacology2025

Eunbi Lee, Juhye Park, Ju-Ock Nam

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Exploration of Phytochemical Constituents inAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eunbi LeeDepartment of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.
Juhye ParkDepartment of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.
Ju-Ock NamDepartment of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The objective of this study was to demonstrate the anti-obesity and anti-inflammatory effects of Methods: The anti-obesity and anti-inflammatory potential of Results: In HFD-induced obese mice, NJFE significantly reduced adipocyte hypertrophy, dyslipidemia, and glucose intolerance, while alleviating adipose tissue inflammation. In 3T3-L1 adipocytes, NJFE suppressed adipogenic differentiation and downregulated adipogenesis-related genes. In RAW264.7 macrophages stimulated with LPS, NJFE markedly reduced inflammatory responses. Furthermore, NJFE attenuated inflammatory responses in 3T3-L1 adipocytes exposed to conditioned medium derived from LPS-stimulated RAW264.7 cells. NJFE also improved mitochondrial function in adipocytes. Conclusion: These findings demonstrate that NJFE not only improves obesity but also alleviates obesity-induced inflammation, supporting its potential as a promising natural therapeutic candidate for the prevention and treatment of obesity and related metabolic disorders.

Indexed as

adipogenesisinflammationNeoshirakia japonica (Siebold & Zucc.) Esser [Euphorbiaceae]obesityphytotherapy

Identifiers

PMID41089834
PMCPMC12515811

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.