Evidence map›Paper›PMID 41089833›Full record

ArticleFrontiers in pharmacology2025

Therapeutic potential of extracellular vesicles derived from

Peiyu Liu, Guiyang He, Yaoxin Lu, Juanjuan He, Faliang Wu, Meng Jia, Shaochang Jia, Ruijie Fan, Hongwei Liang, Bing Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peiyu Liu *Department of Military Psychology, Army Medical University, Chongqing, China.
Guiyang He *Department of Emergency, Nanjing Drum Tower Hospital, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Yaoxin Lu *Lushan Rehabilitation and Sanatorium Center, Jiujiang, China.
Juanjuan He *Department of Emergency, Nanjing Drum Tower Hospital, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Faliang WuLushan Rehabilitation and Sanatorium Center, Jiujiang, China.
Meng JiaDepartment of Emergency, Nanjing Drum Tower Hospital, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Shaochang JiaInstitute of Geriatric Medicine, Jiangsu Province Geriatric Hospital, Nanjing, Jiangsu, China.
Ruijie FanLushan Rehabilitation and Sanatorium Center, Jiujiang, China.
Hongwei LiangDepartment of Emergency, Nanjing Drum Tower Hospital, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Bing LiuLushan Rehabilitation and Sanatorium Center, Jiujiang, China.
Min LiDepartment of Military Psychology, Army Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Extracellular vesicles (EVs) mediate intercellular communication by transferring bioactive molecules. While animal-derived EVs are well studied, plant-derived EVs (plant-EVs) are emerging as stable, low-immunogenic nanocarriers with therapeutic potential. Methods: EVs were isolated by differential ultracentrifugation, characterized by electron microscopy and nanoparticle tracking analysis, and their bioactive components identified by GC -MS. Uptake was assessed in PC12 cells. Behavioral and biochemical effects were tested in mice subjected to chronic restraint stress (CRS), chronic unpredictable mild stress (CUMS), and para-chlorophenylalanine (PCPA)-induced insomnia. Key outcomes included social interaction, sucrose preference, Morris water maze performance, sleep parameters, neurotransmitter levels (5-HT, GABA), and inflammatory markers. Results: Conclusion:

Indexed as

anxietydepressionextracellular vesiclesinsomniaplatycladus orientalis (L.) franco

Identifiers

PMID41089833
PMCPMC12515933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.