ArticleInnovation in aging2025
Accelerated biological aging mediates the association between periodontal disease and cognitive function in older adults.
Article in Innovation in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Oral Health Status, Knowledge, Hygiene Behavior and Cognitive Function Among Older Adults in Shanghai, China.Behavioral sciences (Basel, Switzerland) · 2026Article
- Edentulism, blood-based neurodegenerative biomarkers, and 10-year dementia risk: A mediation analysis in a nationally representative United States cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Silent Inflammation: A Critical Narrative Review of the Relationship Between Periodontal Disease and Psychosis-The Role of Oxidative Stress and Iatrogenic Comorbidities.Antioxidants (Basel, Switzerland) · 2026Review
- Oral health, genetic susceptibility, and risk of dementia: a prospective cohort study of UK Biobank.GeroScience · 2026Article
- Oral health conditions and domain-specific cognitive decline in older adults: evidence from the Baltimore Longitudinal Study of Aging 2005-2024.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- [Aging-Associated Oral Microbiota Dysbiosis and Hypofunction: Their Role in Alzheimer's Disease Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Number of natural teeth and intrinsic capacity among hospitalized older adults in China: a cross-sectional study on the role of social support.Frontiers in medicine · 2026Article
- Divergent effects of oral health and genetic risk: competing risks of dementia and mortality.Innovation in aging · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Periodontitis is a prevalent chronic inflammatory gum disease in older adults and has been linked to cognitive decline, but underlying mechanisms are unclear. The geroscience hypothesis provides a framework for this link, positing that fundamental aging processes (eg, chronic inflammation) drive multiple age-related diseases. We aimed to determine whether accelerated biological aging mediates the association between periodontal disease and cognitive function in older adults. Research Design and Methods: Data were analyzed from 1950 adults aged ≥60 years in the National Health and Nutrition Examination Survey 1999-2002. Periodontal status was clinically assessed (mean clinical attachment loss [CAL], periodontal probing depth [PD], and periodontitis defined by CDC/AAP thresholds). Cognitive performance was measured with the Digit Symbol Substitution Test (DSST). Biological aging was quantified using Klemera-Doubal method (KDM) and Phenotypic Age (PhenoAge) algorithms. Multivariable linear regressions and mediation analyses (adjusted for sociodemographic, behavioral, and health factors) were conducted to evaluate associations and the proportion of the periodontal-cognition link mediated by biological age acceleration (BAA). Results: Periodontitis was significantly associated with poorer cognitive function (DSST standardized β=-0.095, Discussion and Implications: Accelerated biological aging partially mediates the relationship between periodontal disease and cognitive function, supporting a novel geroscience-based mechanism linking oral inflammation and cognitive decline. Future interventions targeting oral health could simultaneously mitigate systemic aging and protect cognitive function.
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