Evidence map›Paper›PMID 41089789›Full record

ReviewReviews in cardiovascular medicine2025

New Fuels for a Failing Engine: The Impact of Novel Heart Failure Drugs on Functional Capacity.

Nikita Baracchini, Teresa Maria Capovilla, Simona Costantino, Fiorella Puttini, Elisabetta Salvioni, Irene Mattavelli, Massimo Valenti, Emilia d'Elia, Elena Bertarelli, Piergiuseppe Agostoni and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nikita BaracchiniCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, 34149 Trieste, Italy.ORCID https://orcid.org/0000-0003-1408-8544
Teresa Maria CapovillaCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, 34149 Trieste, Italy.
Simona CostantinoCentro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
Fiorella PuttiniCentro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
Elisabetta SalvioniCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, 34149 Trieste, Italy.
Irene MattavelliCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, 34149 Trieste, Italy.
Massimo ValentiCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, 34149 Trieste, Italy.
Emilia d'EliaCardiovascular Department, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
Elena BertarelliCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, 34149 Trieste, Italy.
Piergiuseppe AgostoniCentro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
Gianfranco SinagraCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, 34149 Trieste, Italy.
Massimo MapelliCentro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional impairment is a hallmark of heart failure (HF) and a strong prognostic factor. Cardiopulmonary exercise testing (CPET) provides a robust and objective assessment of exercise capacity; however, the impact of new pharmacotherapies on CPET parameters remains largely uncharacterized systematically. This review examines the influence of contemporary HF therapies on functional capacity, with particular focus on CPET-derived metrics, such as peak oxygen uptake (VO

Indexed as

cardiopulmonary exercise testingfunctional capacityheart failurenovel drugs

Identifiers

PMID41089789
PMCPMC12516751

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.