Evidence map›Paper›PMID 41089766›Full record

Trial reportOpen forum infectious diseases2025

Evaluation of the Safety of Cefazolin Monotherapy in Outpatient Parenteral Antimicrobial Therapy at a Large Academic Medical Center.

Nicolas Poux, Eric Gillett, Catherine Franklin, Mark Estano, Helen S Stevenson, Charles Dewan, Brandon Dionne, David W Kubiak, Jeffrey C Pearson, Brian T Chan

Abstract readClinical Trial
In one paragraph

Trial report in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicolas PouxMD-PhD Program, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1084-4533
Eric GillettDepartment of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9528-8526
Catherine FranklinDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mark EstanoDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Helen S StevensonDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Charles DewanDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Brandon DionneDepartment of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2851-8883
David W KubiakDepartment of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-3133-0945
Jeffrey C PearsonDepartment of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5276-1050
Brian T ChanDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6971-3039

Funding

Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Molecular, Cellular, and Developmental MechanismsT32GM145407 · NIGMS · HARVARD MEDICAL SCHOOL · PI David L. Van Vactor · 2022 to 2026
$5.2M
NIGMS NIH HHS T32 GM144273NIGMS NIH HHS T32 GM145407
6 · The paper itself

Abstract

In outpatient parenteral antimicrobial therapy, weekly lab monitoring is often standard practice, even for antimicrobials with low complication rates. We reviewed 420 patients treated with cefazolin: lab abnormalities associated with readmission or treatment changes occurred in 2% of patients. Reduced-frequency monitoring may be reasonable for patients treated with cefazolin outpatient.

Indexed as

adverse eventscefazolinhealthcare resource utilizationlaboratory monitoringoutpatient parenteral antimicrobial therapy

Identifiers

PMID41089766
PMCPMC12517271

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.