ArticleMaterials today. Bio2025
Engineering macrophage responses through 3D scaffold microarchitecture.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Mechano-immunomodulatory biomaterials: From immune mechanosensing to translational design.Bioactive materials · 2026Review
- In vivo validation of multimodality pore-network modeling to identify angio-permissive scaffold porosity.Materials today. Bio · 2026Article
- From Smart Hydrogel Design to 4D-Printed Scaffolds: Emerging Paradigms in Precision Drug Delivery and Regenerative Wound Therapy.Gels (Basel, Switzerland) · 2026Review
- Collagen-Enriched Immunomodulatory Hydrogel for Tendon Regeneration.Gels (Basel, Switzerland) · 2026Article
- Three-Dimensional Printing of a Spinal Interbody: Design Principles, Biomaterials, and Translational Considerations.Journal of functional biomaterials · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomaterial implantation in living tissues triggers a physiological response known as foreign body reaction, leading to the recruitment of macrophages, that can polarize either into a pro-inflammatory (M1) or an anti-inflammatory (M2) phenotype. Currently, there is growing interest in tailoring the physical properties of biomaterials to promote efficient tissue regeneration. Tridimensionality can profoundly influence macrophage behaviour; however, there is no clear consensus on the underlying mechanisms. 3D microstructures may play a crucial role in modulating immune cells, promoting anti-inflammatory responses, and supporting effective tissue repair and regeneration. In this study, we designed and fabricated 3D scaffolds with large pores (50 × 50 × 20 μm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.