SynthesisFrontiers in immunology2025
Impact of recent COVID-19 infection on liver and kidney transplantation - a worldwide meta-analysis and systematic review.
Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Introduction: The shortage of suitable donor organs represents an ongoing global challenge for organ transplantation. During the COVID-19 pandemic, the number of transplantable organs was especially limited. To date, the impact of recent coronavirus-19 (COVID-19) infection on liver and kidney transplant recipients has not been systematically analyzed, which is essential for the development of future transplant management. Methods: We conducted a systematic review and meta-analysis to assess the clinical outcomes of recent COVID-19 infection in the donor (1) or the recipient (2). A total of 17 studies were considered for systematic review, seven of these were included for meta-analysis. Results: Transplantation of COVID-19 positive donors did not result in an impaired graft survival for liver or kidney transplantation up to 180-days of follow up. Additionally, a positive COVID-19 donor status was not associated with decreased overall survival in kidney transplant recipients within 180 days of transplantation. Nevertheless, an association was found with decreased overall survival in liver transplant recipients within the 180-day follow-up period. Discussion: However, the heterogeneity of studies investigating COVID-19 infection of the recipient did not allow a classification of the significance of COVID-19 positive recipients. Conclusively, a COVID-19 positive donor status should not be considered as an exclusive factor for declining a suitable liver or kidney for transplantation. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024562551.
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