ReviewFrontiers in immunology2025
Developmental trajectory of long-lived plasma cells.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Long-Lasting Antibody and CD8Vaccines · 2026Article
- Viral Vaccine Adjuvant Strategies for Shaping Durable Immunity Across the Human Lifespan.Vaccines · 2026Review
- Schistosomiasis vaccine SchistoShield® induces functional immune memory responses in US and African populations.NPJ vaccines · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-lived plasma cells (LLPCs), which continuously secrete antibodies, play a central role in humoral immunity and form the foundation of effective vaccine strategies. The anatomical segregation between the tissues where plasma cells are generated and where they are maintained suggests that both cell-intrinsic and extrinsic factors contribute to their longevity; however, the underlying cellular and molecular mechanisms remain largely unclear. In this review, we summarize recent advances in elucidating the regulation of plasma cell survival at both induction and effector sites. We particularly highlight potential LLPC precursors among newly generated plasma cells in secondary lymphoid tissues, and their subsequent maturation and differentiation into bona fide LLPCs within the bone marrow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.