ArticleFrontiers in immunology2025
Scalp seborrheic dermatitis demonstrates a skewing of Th1 activation: a proteomic study in lesional skin.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Mechanisms in Seborrheic Dermatitis-Systematic Review.International journal of molecular sciences · 2026Pooled it
- Reanalysis of the immunological characteristics of scalp psoriasis: a cross-sectional study using Olink proteomics.Frontiers in medicine · 2026Article
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Authors and funding
5 authors.
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Abstract
Introduction: Scalp seborrheic dermatitis (SSD) is a common, chronic inflammatory skin disease. Its pathogenesis and immunological features have been poorly studied. Objective: To elucidate the molecular profile of adult patients with SSD in lesional scalps. Methods: Using punch biopsies, we assessed 92 inflammatory biomarkers in the lesional scalps of SSD patients (n=16) and demographically matched healthy controls (HCs; n=12) via Olink high-throughput proteomics. Results: We identified 16 differentially expressed proteins (DEPs) between lesional scalps of patients with SSD and those of HCs. SSD lesional scalps demonstrated significantly greater expressions of proteins related to T-cell/lymphocyte activation, the cytokine storm signaling pathway and the CGAS-STING signaling pathway. Ingenuity pathway analysis (IPA) highlighted Th1 skewing. These data suggest that SSD is associated with Th1 skewing and the dysregulation of lipid metabolism. Conclusion: These analyses provide a rationale for novel treatment approaches for SSD patients, mainly those targeting Th1 pathways.
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