ArticleFrontiers in neuroscience2025
Analysis of the correlation between serum vitamin D and hypothalamic-pituitary-adrenal axis hormone levels in patients with post-traumatic stress disorder.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Vitamin D and Postpartum Depression: A Narrative Review.Clinics and practice · 2026Review
- Association between vitamin D deficiency and the 8-year risk of incident depression in patients with rheumatoid arthritis: a cohort study.Frontiers in nutrition · 2026Article
- Association between post-traumatic stress disorder levels and serum inflammatory factors in patients undergoing digit replantation.Frontiers in neuroscience · 2025Article
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Authors and funding
6 authors.
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Abstract
Objective: Post-Traumatic Stress Disorder (PTSD) is a psychological disorder triggered by extreme traumatic events. It is characterized by impaired cognitive function and neuroendocrine dysfunction, particularly dysregulation of the hypothalamic-pituitary-adrenal axis. In recent years, the role of vitamin D in neuroprotection and cognitive function has garnered increasing interest; however, its relationship with hypothalamic-pituitary-adrenal (HPA) axis hormone levels in patients with post-traumatic stress disorder (PTSD) remains poorly understood. Methods: This study aimed to investigate the correlation between serum vitamin D levels and HPA axis hormones in patients with PTSD. A total of 96 patients with severe trauma admitted to Rizhao People's Hospital between March 2022 and December 2024 were enrolled and categorized into PTSD and non-PTSD groups according to diagnostic criteria. PTSD symptoms were evaluated using the PTSD Checklist-Civilian Version. Serum levels of 25-hydroxyvitamin D, corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol were measured. Spearman's correlation analysis and receiver operating characteristic curves were employed to assess associations between vitamin D, HPA axis biomarkers, and PCL-C Scores. Results: The results showed that serum 25-hydroxyvitamin D levels were significantly lower in the PTSD group compared to the non-PTSD group ( Conclusion: This study demonstrated a correlation between serum vitamin D levels and HPA axis hormone levels in patients with PTSD, suggesting that vitamin D deficiency may be associated with HPA axis dysregulation in PTSD. These findings underscore a potential link between vitamin D deficiency and PTSD, warranting further investigation into the role of vitamin D in the disorder's pathophysiology and its potential as a therapeutically modifiable factor.
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