ArticleMedical journal of the Islamic Republic of Iran2025
Investigating IgG Levels in Pediatrics with Kawasaki Disease and Its Association with Clinical Outcomes: A Cross-Sectional Study.
Article in Medical journal of the Islamic Republic of Iran, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Kawasaki Disease is a type of systemic vasculitis. Patients diagnosed with Kawasaki Disease require a regimen of aspirin and intravenous immunoglobulin (IVIG). Timely diagnosis and proactive treatment can prevent complications associated with Kawasaki Disease. Therefore, this study was conducted to investigate the levels of IgG in Kawasaki patients and its correlation with clinical outcomes at Taleghani Hospital in Gorgan in 2022. Methods: This cross-sectional study was conducted on 36 Kawasaki patients admitted to Taleghani Hospital in Gorgan in 2022. Patients were categorized into two groups based on Kawasaki criteria: complete and incomplete. Levels of IgG and primary disease characteristics, laboratory findings, and echocardiographic results were measured and recorded. Data was collected using a researcher-made checklist through observation, examination, and interview. Data were analyzed using an independent t-test and a Chi-square test at the 0.05 level, as determined by SPSS version 23. Results: The results showed that the average age of the children was 26.43 ± 21.88 months, with 63.9% of the samples aged between 1 and 5 years. 89.2% did not have coronary involvement, and 91.7% responded to treatment. Leukopenia was present in 2.8% of children, leukocytosis in 75%, and 36% were in the acute phase. Inflammatory factors ESR and CRP were positive in 72.2% of children. The average IgG level in female children was higher than in males, but this difference was not significant. The frequency of laboratory diagnosis was less in boys than in girls, but this difference was also not significant. Conclusion: Timely diagnosis and proactive treatment (IVIG) can prevent complications associated with Kawasaki Disease. Paraclinical findings play a significant role in determining the response to treatment and clinical outcomes.
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