ArticleMedical journal of the Islamic Republic of Iran2025
Microalbuminuria Predicts Elevated Right Ventricular Filling Pressure in Non-Obstructive Coronary Artery Disease.
Article in Medical journal of the Islamic Republic of Iran, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: While microalbuminuria is established in left heart dysfunction prognostication, its relationship with right ventricular (RV) function remains unclear. We investigated whether microalbuminuria predicts early-stage RV dysfunction in patients with normal coronary arteries. Methods: This cross-sectional analysis involved 117 patients with angiography-verified non-obstructive CAD. Comprehensive RV echocardiography (including E/e' ratio) and morning urine albumin-creatinine ratio (UACR) measurements were performed. The study patients were categorized into 67 with normal albuminuria (mAlb (-): UACR <30 mg/g) and 50 with microalbuminuria (mAlb (+): UACR 30-300 mg/g). Multivariable logistic regression evaluated microalbuminuria's relationship with RV metrics, adjusting for sex, age, and BMI. A Results: The mAlb (+) group demonstrated significantly higher RV E/e' ratios ( Conclusion: Microalbuminuria independently associates with elevated RV filling pressures in non-obstructive CAD patients, suggesting shared microvascular pathophysiology. This supports albuminuria screening's potential role in identifying subclinical RV dysfunction, though longitudinal studies are needed to establish causality.
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