Evidence map›Paper›PMID 41089601›Full record

ArticleMolecular and clinical oncology2025

Multicenter validation of CEACAM6 and FOXP3 as robust prognostic biomarkers in colon cancer: Combined immunohistochemical and transcriptomic analysis.

Yingying Liu, Jianxin Ye, Jinzhao Ma, Xingxiao Pan

Abstract read
In one paragraph

Article in Molecular and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yingying LiuDepartment of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214000, P.R. China.
Jianxin YeDepartment of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Jinzhao MaDepartment of Reproductive Medicine, Eastern Theater Command General Hospital, Nanjing, Jiangsu 210002, P.R. China.
Xingxiao PanDepartment of Gastroenterology, Jiangsu Provincial Veterans Hospital, Wuxi, Jiangsu 214000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colon cancer remains a leading cause of cancer-related mortality worldwide, with metastatic disease exhibiting particularly poor prognosis. To identify robust prognostic biomarkers, the present multicenter study employed immunohistochemistry and reverse transcription-quantitative PCR to evaluate CEACAM6 and FOXP3 expression in 301 colon cancer specimens from three tertiary hospitals in China, analyzing their associations with tumor-infiltrating lymphocytes, clinicopathological features and patient outcomes. Key findings revealed that early-stage (I-II) tumors exhibited significantly higher infiltration of CD3

Indexed as

CEACAM6colon cancerFOXP3multicenter studyprognostic biomarkerstumor-infiltrating lymphocytestumor microenviro-nment

Identifiers

PMID41089601
PMCPMC12517127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.