Evidence map›Paper›PMID 41089589›Full record

ArticleClinical hypertension2025

Sesame and cardiovascular balance: a GRADE-assessed systematic review and meta-analysis of its role in modulating risk factors among individuals with prehypertension and hypertension.

Helia Mardani, Faezeh Ghalichi, Zahra Mirzaei Fashtali, Sara Jamei Ardakany, Matin Abdollahi Yousefabady, Arefeh Mohajerani, Vali Musazadeh, Ali Jafari

Abstract read
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In one paragraph

Article in Clinical hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Helia MardaniStudents' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0009-0003-2323-3464
Faezeh GhalichiDepartment of Nutrition Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.ORCID https://orcid.org/0000-0002-3504-8069
Zahra Mirzaei FashtaliStudent Research Committee, Semnan University of Medical Sciences, Semnan, Iran.ORCID https://orcid.org/0009-0000-5854-7496
Sara Jamei ArdakanyStudent Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.ORCID https://orcid.org/0009-0005-4507-4454
Matin Abdollahi YousefabadyStudent Research Committee, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID https://orcid.org/0000-0002-7695-1000
Arefeh MohajeraniStudents' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-8631-4921
Vali MusazadehStudent Research Committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-4978-9474
Ali JafariStudent Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-7343-027X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This systematic review aimed to evaluate the clinical effectiveness of sesame supplementation on cardiovascular health parameters in pre-hypertensive and hypertensive individuals. Methods: A systematic search was conducted up to August 2024.Eligible studies evaluated the effects of sesame supplementation on blood pressure, anthropometric indices, lipid profiles, and oxidative stress markers. Study quality and evidence strength were assessed using the Cochrane Risk of Bias tool and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach, respectively. Results: Six trials, with interventions ranging from 4 to 8 weeks and involving 465 participants, reported reductions in body mass index (weighted mean difference [WMD], -3.00 kg/m Conclusions: While sesame supplementation showed apparent improvements in several cardiovascular risk factors, the very low certainty of evidence, driven by study limitations and implausible effect sizes, precludes definitive conclusions. High-quality, well-designed randomized controlled trials are needed to clarify sesame's therapeutic role in prehypertension and hypertension. Trial Registration: PROSPERO Identifier: CRD42025634033.

Indexed as

Blood pressureDietary interventionHypertensionMeta-analysisMetabolic factorsSesame

Identifiers

PMID41089589
PMCPMC12517697

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.