Evidence map›Paper›PMID 41089572›Full record

ReviewCureus2025

Azelaic Acid in Dermatology: A Review of Its Mechanism of Action.

Camilo Mariano-Rodriguez, Pamela Nava-Martinez, Valeria Lyzzete Diaz-Molina

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Camilo Mariano-RodriguezDermatology, General Hospital of México "Dr. Eduardo Liceaga", Mexico City, MEX.
Pamela Nava-MartinezFamily Medicine, National Autonomous University of Mexico, Mexico City, MEX.
Valeria Lyzzete Diaz-MolinaDermatology, General Hospital of México "Dr. Eduardo Liceaga", Mexico City, MEX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Azelaic acid (AzA) is a naturally occurring dicarboxylic acid initially studied for its role in skin hypopigmentation and later developed for treating hyperpigmentary disorders due to its tyrosinase inhibition. Over time, AzA has demonstrated therapeutic potential in various dermatological conditions due to its multifaceted mechanisms of action, which remain not entirely understood. This incomplete understanding represents a significant limitation, as elucidating the molecular and cellular pathways involved may not only optimize its current clinical applications but also facilitate the identification of novel therapeutic indications. A comprehensive review of its mechanisms is therefore essential to support evidence-based use and encourage future research into its broader dermatological potential.

Indexed as

azelaic acidclinical usedermatologymechanism of actionpharmacology

Identifiers

PMID41089572
PMCPMC12517662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.