ArticleHealth science reports2025
Comparative Evaluation of Kidney Function Using Cystatin C and Serum Creatinine in Cirrhosis Patients: A Prospective Cross-Sectional Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparative Evaluation of Kidney Function Using Cystatin C and Serum Creatinine in Cirrhosis Patients: A Prospective Cross-Sectional Study.Health science reports · 2025Article
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10 authors.
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Abstract
Background and Aim: Accurate assessment of kidney function in patients with cirrhosis remains challenging due to the limitations of traditional biomarkers. This study aimed to compare the utility of serum creatinine (Cr) and cystatin C (Cys) in evaluating kidney function across different stages of disease severity. Methods: This prospective cross-sectional study enrolled 120 participants at Jinnah Postgraduate Medical Centre, Karachi, Pakistan, comprising 30 healthy controls and 90 patients with cirrhosis, equally distributed across Child-Pugh Classes A, B, and C. Comprehensive clinical assessment included measurement of serum Cr and Cys, with estimation of glomerular filtration rate (eGFR) using CKD-EPI 2021 equations based on Cr, Cys, and combined Cr-Cys. The Cr/Cys ratio was calculated to assess the degree of discordance between these biomarkers and kidney function was further classified into chronic kidney disease (CKD) stages according to the respective eGFR estimation methods. Results: Serum Cr was elevated in cirrhosis than controls with no difference between patient groups, whereas Cys showed a progressive increase with advancing cirrhosis and disease severity ( Conclusion: Cys, alone or integrated with Cr in CKD-EPI equations, provides a more sensitive assessment of kidney dysfunction with increasing cirrhosis and disease severity.
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