ArticleFrontiers in reproductive health2025
Temporal shifts in semen parameters across a major COVID-19 outbreak wave: a retrospective cohort study using epidemiological time-windows.
Article in Frontiers in reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the temporal variations in male semen quality parameters before, during, and after a major regional COVID-19 outbreak wave. Methods: This retrospective cohort study analyzed initial semen samples collected at our hospital between June 1, 2022, and June 30, 2023. Based on regional epidemiological data corresponding to a major outbreak, participants were stratified into three groups by sample collection date: a pre-outbreak group (Group A, September 1, 2022-December 31, 2022, Results: The peak-outbreak group (Group B) showed significantly lower sperm concentration compared to both the pre-outbreak group (49.1 vs. 59.6 × 10 Conclusion: Semen concentration and motility were significantly lower in samples collected during the peak of a major COVID-19 outbreak wave, with parameters returning to pre-outbreak levels in the subsequent 3-month period. Key sperm functional biomarkers, including acrosin activity and DNA integrity, appeared resilient throughout these distinct epidemiological phases.
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