Evidence map›Paper›PMID 41089497›Full record

ArticleACS medicinal chemistry letters2025

Inhibitors of Serine Acetyltransferase Induce Lethality in

Sudhaker Dharavath, Priya Tomar, Faraz Mohd Khan, Gargi Bhrigu, Vijayan Ramachandran, Evanka Madan, Rohini Muthuswami, Samudrala Gourinath

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sudhaker DharavathStructural biology lab, School of Lifesciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Priya TomarStructural biology lab, School of Lifesciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Faraz Mohd KhanStructural biology lab, School of Lifesciences, Jawaharlal Nehru University, New Delhi, 110067, India.ORCID https://orcid.org/0000-0002-5754-7088
Gargi BhriguChromatin Remodeling Laboratory, School of Lifesciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Vijayan RamachandranStructural biology lab, School of Lifesciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Evanka MadanChromatin Remodeling Laboratory, School of Lifesciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Rohini MuthuswamiChromatin Remodeling Laboratory, School of Lifesciences, Jawaharlal Nehru University, New Delhi, 110067, India.ORCID https://orcid.org/0000-0002-0559-9484
Samudrala GourinathStructural biology lab, School of Lifesciences, Jawaharlal Nehru University, New Delhi, 110067, India.ORCID https://orcid.org/0000-0003-4090-3063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The limited efficacy and emerging resistance to current antiamoebic agents highlight the urgent need for new therapies. Serine acetyltransferase isoform 3, essential for cysteine biosynthesis in

Indexed as

dose-dependent inhibitionIC50 - half maximal inhibitory concentrationin vivo cell growth inhibitionMD simulationsSerine acetyltransferase

Identifiers

PMID41089497
PMCPMC12516369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.