ArticleACS medicinal chemistry letters2025
Discovery of Rogocekib (CTX-712): A Potent and Selective CLK Inhibitor for Cancer Treatment.
Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Unique fluoroalkyl substituents: is there life after CFChemical science · 2026Review
- Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies.Cellular oncology (Dordrecht, Netherlands) · 2026Review
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Authors and funding
20 authors.
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Abstract
Cdc2-like kinase (CLK) inhibitors represent an innovative class of small molecules designed to modulate RNA splicing patterns, offering a novel avenue for therapeutic intervention in diseases where dysregulated splicing contributes to pathogenesis, particularly in oncology. Here, we describe the discovery of Rogocekib (CTX-712), a promising therapeutic candidate as a CLK inhibitor, which is currently in clinical development. Our medicinal chemistry research involved structure-based drug design-guided scaffold hopping from an initial chemical scaffold and subsequent chemical optimization to generate a novel 1
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