Evidence map›Paper›PMID 41089475›Full record

ArticleACS medicinal chemistry letters2025

Spiro Hydantoins Can Reverse the Action of Positive Allosteric Modulators on GABA

Dimosthenis A Koinas, Xiaojuan Zhou, Karol S Bruzik, Keith W Miller

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dimosthenis A KoinasDepartment of Pharmaceutical Sciences, University of Illinois Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, United States.ORCID https://orcid.org/0000-0002-6684-931X
Xiaojuan ZhouDepartment of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, United States.
Karol S BruzikDepartment of Pharmaceutical Sciences, University of Illinois Chicago, 833 South Wood Street, M/C 781, Chicago, Illinois 60612-7231, United States.ORCID https://orcid.org/0000-0003-0678-4232
Keith W MillerDepartment of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, United States.ORCID https://orcid.org/0000-0002-4105-6639

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Molecular Pharmacology of the Synaptic and Extrasynaptic GABA(A) ReceptorsR01GM135550 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 2020 to 2023
$2.8M
NIGMS NIH HHS P41 GM103311NIGMS NIH HHS R01 GM135550
6 · The paper itself

Abstract

GABA

Indexed as

Allosteric modulatorsAnestheticGABAARHydantoinReversal agent

Identifiers

PMID41089475
PMCPMC12516361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.