Evidence map›Paper›PMID 41089474›Full record

ArticleACS medicinal chemistry letters2025

Identification and Exploration of a Series of SARS-Cov‑2 M

Emma Clyde-Allen, Mikołaj Zmudzinski, Mohammad Afsar, Ciyana James, Anindita Nayak, Digant Nayak, Priscila Dos Santos Bury, Dirk Jochmans, Johann Neyts, Christopher J Scott and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emma Clyde-AllenProtease Drug Development Lab, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, Northern Ireland.
Mikołaj ZmudzinskiDepartment of Chemical Biology and Bioimaging, Wrocław University of Science and Technology, 50-370 Wroclaw, Poland.ORCID https://orcid.org/0000-0002-9792-9160
Mohammad AfsarDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Ciyana JamesProtease Drug Development Lab, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, Northern Ireland.
Anindita NayakDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Digant NayakDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.ORCID https://orcid.org/0000-0003-3680-0846
Priscila Dos Santos BuryDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Dirk JochmansVirology, Antiviral Drug & Vaccine Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.ORCID https://orcid.org/0000-0002-9265-6028
Johann NeytsVirology, Antiviral Drug & Vaccine Research Group, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
Christopher J ScottFuture Medicines Institute, Queen's University Belfast, Belfast BT9 7AE, Northern Ireland.ORCID https://orcid.org/0000-0002-7582-3808
Shaun K OlsenDepartment of Biochemistry & Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Marcin DragDepartment of Chemical Biology and Bioimaging, Wrocław University of Science and Technology, 50-370 Wroclaw, Poland.ORCID https://orcid.org/0000-0001-8510-1967
Rich WilliamsProtease Drug Development Lab, Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, Northern Ireland.ORCID https://orcid.org/0000-0002-7710-2975

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Starting from a simple scaffold hopping exercise based on our previous exploration of cysteine protease inhibitors against legumain, compound

Indexed as

COVID-19 infectionMPro inhibitionProtease inhibitorReversible small molecule designViral proteaseViral replication

Identifiers

PMID41089474
PMCPMC12516390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.