ArticleACS medicinal chemistry letters2025
Discovery of the U2AF1-UHM Inhibitor That Possesses Anti-Leukemia Activity In Vitro.
Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In the early step of RNA splicing, U2AF1 and U2AF2 form a heterodimer that binds to the 3' exon-intron junction to define the 3' splice site. Mutations of U2AF1 dysregulate the splicing process and are frequently observed in subtypes of hematological neoplasms. No potent inhibitor of U2AF1 has been reported. Here, we report on the development of
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