ReviewTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2025
Prevalence of Alloimmunization and Associated Risk Factors among Antenatal Women in India: A Systematic Review and Meta-Analysis.
Review in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- "Baby You're Just Not Right for Me": The Various Problems of Feto-Maternal Incompatibilities.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025Article
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Authors and funding
6 authors.
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Abstract
Background: Maternal alloimmunization can lead to significant perinatal morbidity and mortality. The rate of maternal alloimmunization reported is varied across the studies conducted in India. A systematic review will help in understanding the overall prevalence of alloimmunization. Additionally, the study aimed at understanding the factors affecting the rate of maternal alloimmunization. Methods: A search of original articles reporting rate of alloimmunization among antenatal women published in English language from India was performed in Scopus, Google Scholar, MEDLINE, and CINAHL databases. Two independent teams, each comprising two reviewers, extracted data from the eligible studies. Meta-analysis was performed for cumulative estimates by binary random-effects model using the restricted maximum likelihood method. Results: Fourteen studies published between 2011 and 2023 were included. The pooled prevalence of maternal alloimmunization was 2.0 per 100 (95% CI: 1.5-2.5) among antenatal women, with significant heterogeneity across studies. Anti-D was the most frequently identified antibody (56.39%), followed by anti-D + anti-C (10.68%) and anti-E (5.71%). Higher risk of alloimmunization was observed in women with Rhesus D-negative blood group, multigravida status, history of blood transfusion, and bad obstetric history. Conclusion: Despite the availability of anti-D prophylaxis, over half of the alloimmunized women had anti-D antibodies, indicating potential gaps in prevention strategies. Further research is needed to understand these gaps and implement effective interventions to minimize this preventable cause of fetal and neonatal complications. For girls and women of reproductive age, providing prohylactic antigen-matched (Rh and Kell) red cell units when transfusion is needed may reduce the burden of red cell alloimmunization.
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