ArticleFrontiers in microbiology2025
Guiren Runchang granules alleviate slow transit constipation in mice by modulating gut microbiota and short-chain fatty acids.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- [Research progress of metabolomics in the pathogenesis and treatment of constipation in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Live and Heat-InactivatedNutrients · 2026Article
- Kaempferol Ameliorates Functional Constipation in Mice by Regulating Autophagy of Interstitial Cells of Cajal via the p53/AMPK/mTOR Axis.Digestive diseases and sciences · 2026Article
- Microbiota-immune-enteric nervous system interactions in functional constipation: a narrative review and hypothesis-generating framework.Frontiers in immunology · 2026Review
- Ultrasound-assisted extraction of total saponins fromCurrent research in food science · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Guiren Runchang Granules (GRG), a traditional Chinese medicine (TCM) formulation, has demonstrated effectiveness in treating slow transit constipation (STC). This study investigated the therapeutic effects of GRG on constipated mice, focusing on its role in restoring intestinal micro-ecology. The results showed that GRG treatment significantly improved defecation in STC mice and ameliorated intestinal histopathological damage. GRG effectively normalized colonic and serum motility-related hormone levels (5-HT, SP, MTL, and SS) with comparable efficacy to mosapride, a prokinetic agent. In addition, GRG treatment restored the balance of the gut microbiota and increased the levels of short-chain fatty acids (SCFAs). Specifically, the relative abundance of the genera
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