ReviewJB & JS open access
Inflammatory Bowel Disease and Adverse Outcomes After Total Joint Arthroplasty: A Systematic Review and Meta-Analysis.
Review in JB & JS open access. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inflammatory Bowel Disease (IBD) is associated with systemic inflammation and which might influence surgical outcomes. As total joint arthroplasty (TJA) becomes increasingly common in this population as they age, this study aimed to evaluate whether IBD is associated with increased postoperative complications following total hip or knee arthroplasty. Methods: We performed a systematic review of studies including patients with and without IBD undergoing TJA. Databases searched included PubMed, Scopus, Web of Science, and Embase through February 24, 2025. Eligible studies included adults with a confirmed diagnosis of IBD who underwent TJA. Meta-analyses were conducted using random-effects models with 95% confidence intervals. Results: Fourteen studies comprising 2,651,318 patients (86,581 with IBD) met inclusion criteria. IBD was significantly associated with increased risks of PJI (OR: 1.47), hospital readmission (OR: 1.39), pneumonia (OR: 1.92), PTE (OR: 1.61), VTE (OR: 1.59), DVT (OR: 1.60), ileus (OR: 5.7), C. difficile infection (OR: 3.3), MI (OR: 2.12), CVA (OR: 2.90), UTI (OR: 2.31), sepsis (OR: 1.83), respiratory failure (OR: 2.17), revision surgery (OR: 1.38), periprosthetic fracture (OR: 1.82), wound (OR: 1.52) and implant complications (OR: 1.62). Length of hospital stay was marginally longer (SMD: 0.06). Mortality and non-home discharge did not differ significantly between groups. Conclusion: Patients with IBD undergoing TJA are at an elevated risk for some postoperative complications, especially infections, thromboembolic events, and revision surgeries. These findings support personalized management strategies in this population. Level of Evidence: Level IIIa. See Instructions for Authors for a complete description of levels of evidence.
Identifiers
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Registered trials
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