ArticleFrontiers in bioengineering and biotechnology2025
Lyophilized horizontal platelet rich fibrin promotes the healing of infected burns/wounds by modulating macrophage polarization and fibroblast migration.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Stored L-PRF membranes: safety, morphology, tensile properties, and cell viability-an in vitro pilot study.Scientific reports · 2026Article
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9 authors.
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Abstract
Background: The treatment of infected burns is a major clinical challenge. Platelet-rich fibrin produced via horizontal centrifugation (H-PRF) has been characterized with antimicrobial and tissue regenerative properties. Noteworthy, its lyophilized form (Ly-H-PRF), which can be conveniently preserved, may also have similar regenerative potential for the treatment of infected burns. The aim of this study was to investigate whether Ly-H-PRF could promote wound healing and its regulatory mechanism in various Methods: Venous blood of healthy volunteers was drawn, horizontally centrifuged at 700 RCF for 8 min, and lyophilized to obtain Ly-H-PRF. Ly-H-PRF was dissolved in culture medium, and its antimicrobial effects were evaluated on Results: Ly-H-PRF effectively inhibited the growth of S.a and E.c. It also protected macrophages from LPS-stimulated apoptosis and reduced LPS-induced macrophage M1 polarization and promoted M2 polarization. Ly-H-PRF further protected fibroblasts from LPS-stimulated apoptosis and facilitated fibroblasts migration. In the Conclusion: The present study demonstrated that Ly-H-PRF promoted the healing of infected burn wounds by exerting an antibacterial effect, regulating macrophage polarization, and promoting skin fibroblast migration. Our results provide a pre-theoretical basis for the clinical application of Ly-H-PRF as an economical and convenient treatment for infection control and to promote tissue healing in infected burn wounds.
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