ArticleMedicine international
Papillary thyroid cancer in prepubertal patients: A report of two cases and a brief review of the literature.
Article in Medicine international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although papillary thyroid carcinoma (PTC) is relatively rare in children, particularly in the prepubertal age group, its biological behavior resembles that of other pediatric solid tumors, where delayed diagnosis can significantly affect outcomes. In the broader oncology context, rare pediatric malignancies, such as prepubertal PTC, highlight the importance of tailoring diagnostic and therapeutic strategies to those applied in adults. PTC in prepubertal children is a rare occurrence that presents with a high likelihood of distant metastasis. The present study describes 2 cases of PTC in 9-year-old girls with irrelevant medical, surgical, or family history. The first case was that of a 9-year-old girl with a painless neck swelling for 4 weeks. An ultrasonography revealed diffuse thyroid lesions and cervical lymphadenopathy. She underwent a total thyroidectomy with bilateral neck dissection. Pathological analysis confirmed diffuse sclerosing PTC with numerous positive lymph nodes. She recovered well and received radioactive iodine therapy. The second case was that of a 9-year-old girl with right-sided neck swelling for 1 year. Imaging revealed a Thyroid Imaging Reporting and Data System 5 nodule and suspicious lymph nodes. She underwent a total thyroidectomy with bilateral central and right lateral neck dissection. Pathological analysis confirmed unifocal conventional PTC with 17 positive lymph nodes. She recovered well, received radioactive iodine therapy, and remained recurrence-free for 3 years. In addition, in the present study, a literature search was performed on the PubMed and Google Scholar database, covering the period from January, 2017 to February, 2025. The search used combinations of the following key words: 'papillary thyroid carcinoma', 'papillary thyroid cancer', 'thyroid neoplasm', 'pediatric' and 'prepubertal'. Only articles published in the English language and reporting individual prepubertal PTC cases were considered. From this search, 9 relevant cases were identified and were included in a brief review of the literature, of which 5 cases were females. The ages of the patients ranged from 5 to 17 years. The right thyroid lobe was involved in 4 patients, and bilateral involvement was reported in 1 case. Tumors were multifocal in 7 patients, and lymph nodes were involved in 8 patients. A total of 7 cases were of conventional variation, and distant metastases were reported in 4 cases, all of which were in the lungs. Total thyroidectomy was performed for all the cases. As demonstrated herein, papillary thyroid carcinoma in prepubertal children is uncommon. Total thyroidectomy may provide good long-term outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.