ArticleBrain communications2025
Probabilistic mapping of the antiparkinsonian effects of pallidal deep brain stimulation.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Brain connectivity fingerprinting as a predictive biomarker of art therapy outcomes in Parkinson's disease.Research square · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep brain stimulation of the internal globus pallidus effectively treats motor symptoms and drug-induced fluctuations in advanced Parkinson's disease-but is complicated by a high variability in outcomes. In a minority of patients, even stimulation-induced aggravation of akinesia has been reported. Previous works and clinical practice suppose an antiparkinsonian sweetspot in a sensorimotor segment in ventrocaudal internal globus pallidus. However, the detailed functional anatomy of the nucleus is still a matter of debate. We examined 39 patients with Parkinson's disease undergoing pallidal deep brain stimulation from two centres. Deep brain stimulation outcomes were scaled using the percentage change in the motor part of Unified Parkinson's Disease Rating Scale in MED-OFF pre- and postoperatively. The mean improvement with chronic pallidal deep brain stimulation was 16 ± 37%. Motor symptoms improved in 72% of patients. However, 10% were poor responders (<15% improvement) and 28% experienced a worsening of parkinsonism. After basic data processing, we used individual stimulation parameters to construct volumes of tissue activated and applied an established approach of voxelwise
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Registered trials
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