ArticleOncology letters2025
Anticancer effects of the Kiperin Purple Collagen complex: Evidence from HCT116 and MIA PaCa-2 cell models.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Investigation of the effects of a Kiperin Bromelain & Papain complex in normal colon, mammary, and skin cells.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purple Collagen is a bioactive complex containing double-hydrolyzed collagens (types I, II, III, V and X) and various bioactive components (inulin, elderberry extract, magnesium citrate and malate, eggshell membrane, bromelain, black cumin extract and liposomal vitamin C). These bioactive compounds have attracted increasing scientific interest due to their ability to modulate key cancer-associated pathways, including the inhibition of cell proliferation and migration, suppression of oxidative stress via free radical scavenging and induction of apoptosis through mitochondrial and caspase-dependent mechanisms. While individual components of the Purple Collagen complex (PCC) have been associated with various health benefits, their combined effects on cancer cell behavior remain largely unexplored. The present study investigated the effects of PCC on cell proliferation, migration, oxidative stress and apoptosis in two cancer cell lines: HCT116 (colorectal carcinoma) and MIA PaCa-2 (pancreas carcinoma). The cell viability, migration, oxidative stress [total oxidant status (TOS)/total antioxidant status (TAS)] and apoptotic and cell cycle regulatory markers (
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Registered trials
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