ArticleInternational journal of microbiology2025
Detection of Colistin Heteroresistance in Carbapenem-Resistant
Article in International journal of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- High prevalence of colistin heteroresistance in Pseudomonas aeruginosa bloodstream isolates and associated clinical factors.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Clinical Symptom Resolution Following PCR-Guided vs. Culture and Susceptibility-Guided Management of Complicated UTI: How Time-To-Antibiotic Start and Antibiotic Appropriateness Mediate the Benefit of Multiplex PCR-An Ad Hoc Analysis of NCT06996301.Diagnostics (Basel, Switzerland) · 2025Article
- Genotype-Phenotype Concordance and Ct-Informed Predictive Rules for Antimicrobial Resistance in Adult Patients with Complicated Urinary Tract Infections: Clinical and Stewardship Implications from the NCT06996301 Trial.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Background: Since antimicrobial resistance is a rising danger and a serious threat to the health of humans, recent studies have revealed that routine tests, such as minimum inhibitory concentration (MIC), are not enough to detect heteroresistance (HR) phenotype (i.e., phenotypic heterogeneity in antibiotic susceptibility in the identical bacterial population), and medical laboratories require awareness raising to face it. Colistin is regarded as the final therapeutic option for infections caused by carbapenem-resistant gram-negative bacteria. In this study, we explored the presence of HR to colistin in carbapenem-resistant Methods: From 2019 to 2020, 100 Results: As a result, of the 100 Conclusions: Finally, our study highlights the interplay between HR and its diagnosis methods. Since it is difficult to detect heteroresistant isolates by routine tests in clinical laboratories, it might be misclassified as susceptible and lead to challenges for clinicians and their patients.
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