ArticleF1000Research2025
Evaluation of Salivary HLA-DR4 and MMP-8 Levels Along with
Article in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mass Spectrometry-Based Oral Meta-Omics Analysis-What We Know and What We Don't.Advances in experimental medicine and biology · 2026Review
- Immune checkpoint inhibitor-related arthritis and oral disorders: shared pathophysiology and clinical implications for rheumatology and oral health.Cancer cell international · 2025Review
- Evaluation of Salivary HLA-DR4 and MMP-8 Levels Along withF1000Research · 2025Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periodontitis (PD) is a chronic infectious inflammatory disease that affects the tissues supporting teeth and results in a progressive deterioration of the alveolar bone. Rheumatoid arthritis (RA), a systemic autoimmune disease that has been associated with increased severity of periodontal disease. This study aimed to evaluate the salivary levels human leukocyte antigen-DR4 (HLA-DR4), matrix metalloproteinase-8 (MMP-8), and anti-citrullinated protein antibody (ACPA), and to assess their diagnostic potential using ROC curve analysis in periodontitis patients with and without rheumatoid arthritis. Methods: The study included three groups; thirty patients with PD, thirty patients with PD and RA, and twenty healthy control participants. Clinical periodontal parameters [plaque Index (PLI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL)] were assessed. Salivary biomarkers were analyzed by enzyme-linked immunosorbent assay (ELISA), and the microbial load of Results: Our findings showed that salivary HLA-DR4 levels were significantly lower in patient groups compared with healthy controls (P = 0.000), whereas salivary MMP-8 and ACPA levels were significantly elevated in patients (P = 0.034) and (P = 0.001) respectively, with no significant differences between the patient groups(P > 0.05). On the other hand, microbial load was significantly higher in the PD with and without RA groups than that in controls (P = 0.001), with a positive correlation between microbial load and CAL in the PD-RA group.
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