Trial reportJournal of pain research2025
Clinical Efficacy and Plasma Metabolomics Analysis of Acupuncture for Migraine Treatment.
Trial report in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Acupuncture modulates migraine-related neural and neuroendocrine regulatory pathways.The journal of headache and pain · 2026Review
- Toward Precision Acupuncture for Pain: Host Genetic Variability, Omics Biomarkers, and Treatment-Response Stratification.Human mutation · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Migraine, a prevalent neurological disorder characterized by recurrent, debilitating headaches, poses significant challenges due to limited understanding of its pathophysiology and variable treatment outcomes. Acupuncture has emerged as a promising intervention, yet its clinical efficacy and underlying metabolic mechanisms remain underexplored. This study aimed to evaluate the therapeutic effects of true acupuncture (TA) compared to sham acupuncture (SA) in migraine patients and to elucidate associated metabolic changes using non-targeted plasma metabolomics. Patients and Methods: Fifty-two migraine patients were randomized into TA and SA groups, receiving 12 sessions of acupuncture over four weeks, with clinical assessments and plasma sample collection at baseline and week 4. Results: The TA group exhibited a significant reduction in migraine attack frequency (p<0.05) compared to baseline, while the SA group showed no significant change (p>0.05). Additionally, the TA group demonstrated greater improvements in attack frequency, duration, visual analog scale (VAS) scores, and migraine-specific quality of life (MSQ) emotional and dysfunction subscales compared to the SA group (p<0.05). Metabolomic analysis identified distinct metabolic profiles. TA was associated with five key metabolites, including the lipid regulators 1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE) and Pe (16:0/19,20-epdpe), which correlated with reduced attack duration and improved quality of life scores. In contrast, metabolic changes in the SA group were less pronounced. Pathway analysis revealed that TA predominantly modulated amino acid and pyrimidine metabolism. Conclusion: These findings indicate that TA is more effective than SA in alleviating migraine symptoms, likely through specific regulation of metabolic pathways. The identified metabolites offer potential biomarkers for evaluating treatment response, though further validation is required.
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Registered trials
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