ArticleFrontiers in cardiovascular medicine2025
Characterization of protein lactylation in healthy and ischemic mouse hearts.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate-Induced SNAIL1 K206 Lactylation and Epithelial-Mesenchymal Transition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Global Profiling of Protein Lysine Lactylation in Mouse Cardiac Hypertrophy: A Lactylome Analysis.Journal of cardiovascular development and disease · 2026Article
- Lactate as a Cardiovascular Exerkine: Mechanisms, Signaling Pathways, and Clinical Implications.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recent findings highlight the growing importance of protein lactylation, a modification driven by lactate, in healthy and diseased states. However, its significance in myocardial infarction (MI) remains unclear. Here, we characterized lactylation in healthy and ischemic hearts, revealing its profound implications. Methods: Global proteomics and lactylome profiling were conducted on the hearts of healthy mice and mice with induced MI. Protein expression analysis, enrichment analysis, cellular compartment analysis, and protein-protein interaction network construction were conducted to identify potential molecular features. The changes in total protein lactylation levels and the lactylation levels of identified representative proteins in healthy and ischemic hearts were validated. Results: Proteomic analysis revealed that MI led to a metabolic shift from oxidative phosphorylation and fatty acid Conclusions: We present the first comprehensive lactylation atlas in healthy and ischemic mouse hearts, offering new avenues to explore MI and cardiovascular diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.