ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Accelerated biological aging is associated with cognitive performance among older adults in Mexico, India, United States, and England: A cross-national analysis.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Accelerated biological aging is associated with cognitive performance among older adults in Mexico, India, United States, and England: A cross-national analysis.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionBiological age (BA) measures were developed to capture changes in aging that chronological age does not. We aimed to investigate the association between BA and cognitive performance and whether the Klotho protein mediated this association.
methodsWe used data from participants aged 60 years or older from Mexico, India, the United States, and England. We used linear regression to investigate the association between BA and cognitive performance. Mediation analysis using data from the United States used the counterfactual framework.
resultsIn 8547 participants, 53.6% were women, mean (SD) chronological age was 69.6 (7.6) years and mean (SD) biological age 70.2 (9.6) years. Higher biological age was associated with poorer cognitive performance across all evaluated countries. Klotho did not mediate these associations. DISCUSSION: Implementing the BA metric at the population level could help identify individuals at higher risk of poorer cognitive performance, facilitating targeted interventions. Highlights: Increasing biological age is associated with poorer global cognitive performance in older adults.Accelerated aging is associated with poorer cognitive performance in all countries studied.Klotho did not mediate the association between biological age and cognition.Implementing biological age metrics may help identify high-risk individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.