ReviewFrontiers in allergy2025
Bhopal, Dunsmuir and TRPA1: what they have taught us about nociception.
Review in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On separate occasions nearly a decade apart, two large-scale accidental releases of industrial chemicals exposed substantial "bystander" (non-worker) populations to highly toxic air pollutants. The first of these events, occurring in Bhopal, India in 1984, generated worldwide attention and concern given its geographic scope and significant lethality. The second incident, occurring in Dunsmuir, CA in 1991 - while less publicized - yielded new insights into the pathogenesis of irritant-induced asthma. Linking these events is the fact that the toxicants involved - methyl isocyanate (MIC) in Bhopal and methyl isothiocyanate (MITC) in Dunsmuir - preferentially bind to the same TRPA1 nociceptive ion channel. This review examines each of these exposure events, including their mechanistic implications for anticipating (and potentially preventing) future long-term health effects from accidental chemical exposures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.