ArticleFrontiers in pediatrics2025
A sustained reduction in the rate of severe intraventricular hemorrhage in very low birth weight infants: a novel quality improvement project in a large perinatal-neonatal centre in Asia.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Best evidence summary for the prevention of intraventricular hemorrhage in preterm infants: a systematic review.Translational pediatrics · 2026Review
- Impact of a minimal handling care protocol on intraventricular hemorrhage in preterm infants: a retrospective cohort study.BMC pediatrics · 2026Article
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11 authors.
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Abstract
Objective: Severe IVH (SIVH) stands out as a leading cause of poor neuro-developmental outcomes, including cognitive, attention and motor impairment in very low birth weight (≤1.5 kg, VLBW) infants. The study aims to reduce the rate of severe intraventricular hemorrhage (SIVH) by 50% in very low birth weight (VLBW) infants admitted to the level III C neonatal intensive care unit (NICU) in Singapore. Method: In this quality improvement (QI) study, VLBW infants admitted to NICU from 2011 to 2021 ( Results: Of 2,215 Infants who met the study criteria, Ninety infants were excluded. Detailed data were collected from 2,125 infants (390, 1,000, 370, and 365 in the baseline, intervention, post-intervention, and sustainment periods, respectively). The mean gestational age was 28·6 and 28.8 in the intervention and post-intervention periods, respectively, and were comparable across the 4 study periods. The rate of SIVH was 5.9% in the pre-intervention period and 4.4% and 1.9% (adjusted OR 0.266, Conclusion: A multipronged modified QI approach implementing an evidence-based SIVH prevention bundle and RC-PC-S analysis was associated with a sustained significant reduction in the rate of SIVH in VLBW infants. RC-PC-S is a potential QI tool for reducing severe IVH and other key neonatal morbidities in VLBW infants.
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