ReviewInternational journal of women's health2025
Idiopathic Granulomatous Mastitis: Immune-Pathogen Imbalance in a Treatment-Resistant Benign Inflammatory Disease.
Review in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- An endocrine microbe immunity framework for granulomatous mastitis toward phenotype-oriented interpretation.iScience · 2026Review
- Review
- Idiopathic Granulomatous Mastitis in a Nulliparous Woman With Autism Spectrum Disorder Receiving Long-Term Psychotropic Treatment and Normal Serum Prolactin Level: A Case Report.Clinical case reports · 2026Article
- Article
- Granulomatous mastitis: from localized inflammation to systemic immune-mediated disorder.Frontiers in medicine · 2026Review
- Development and validation of a nomogram for differentiating granulomatous lobular mastitis from ductal carcinoma in situ.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic granulomatous mastitis is a benign non-specific inflammatory disease that occurs in women during non-lactation. Main symptoms in the early stages of disease include red breast lumps, swelling, heat and pain, whereas in the later stages, breast abscesses, sinus tracts, and even ulcers may develop. At present, the etiology and pathogenesis of IGM remains unclear, and there are no standardized guidelines for IGM treatment, which leads to treatment resistance and frequent recurrence, causing serious distress to women's physical and mental health. Based on the existing literature evidence, this paper proposes the "immunity-pathogen imbalance pathogenesis" model, the disease is caused by the imbalance between pathogens and immune system in the breast, resulting in granuloma as the characteristic immune damage response, and Corynebacterium may be the driving factor of the cascade reaction. This article summarizes etiology, diagnostic methods, treatment plans, and recurrence factors, and aims to translate existing mechanisms into a practical clinical framework.
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Registered trials
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