Evidence map›Paper›PMID 41089103›Full record

ArticleCureus2025

Branched-Chain Amino Acids and Testosterone in Older Adults With Type 2 Diabetes: Cross-Sectional and Longitudinal Findings From a Post Hoc Analysis of an Amino Acid Supplementation Trial.

Erika Matsuda, Takaaki Matsuda, Kosuke Kojo, Yoshinori Osaki, Yasuhiro Suzuki, Hiroaki Suzuki, Bryan Mathis, Motohiro Sekiya, Hiroyuki Nishiyama, Hitoshi Shimano

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In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erika MatsudaDepartment of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, JPN.
Takaaki MatsudaDepartment of Endocrinology and Metabolism, University of Tsukuba Hospital, Tsukuba, JPN.
Kosuke KojoDepartment of Urology, University of Tsukuba Hospital, Tsukuba, JPN.
Yoshinori OsakiDepartment of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, JPN.
Yasuhiro SuzukiInstitute of Systems and Information Engineering, University of Tsukuba, Tsukuba, JPN.
Hiroaki SuzukiDepartment of Food and Health Sciences, Faculty of Human Life Sciences, Jissen Women's University, Tsukuba, JPN.
Bryan MathisDepartment of Cardiovascular Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, JPN.
Motohiro SekiyaDepartment of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, JPN.
Hiroyuki NishiyamaDepartment of Urology, Institute of Medicine, University of Tsukuba, Tsukuba, JPN.
Hitoshi ShimanoDepartment of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBranched-chain amino acids (BCAAs) and sex hormones share anabolic effects on skeletal muscle. As cross-sectional associations in older adults with type 2 diabetes (T2D) remain unclear, we analyzed potential causal effects of BCAA supplementation in this population.

methodsThis was an exploratory, post hoc analysis of a 24-week amino acid supplementation trial in older adults with T2D (BCAA 8 g or soy protein 7.5 g). Thirty-five participants (22 men, 13 women) were included. Total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) were measured. Spearman's rank correlation assessed cross-sectional associations, and paired t-tests or Wilcoxon signed-rank tests analyzed pre- and post-supplementation changes.

resultsAt baseline, men showed a negative correlation between serum BCAA and TT (ρ = -0.486) but not FT, whereas women showed positive correlations with both (ρ = 0.446 and 0.657). SHBG correlated negatively with BCAA in both sexes (ρ = -0.452 and -0.571). In the BCAA group, no significant changes in sex hormones were observed after supplementation.

conclusionsCross-sectional associations between serum BCAA and testosterone levels in older adults with T2D were not observed longitudinally and may not reflect direct relationships, but rather influenced by insulin resistance or SHBG levels related to body composition. As this was an exploratory analysis with a small sample size, the results should be interpreted with caution.

Indexed as

aged adultanabolic agentsbody compositionbranched-chain amino acids (bcaas)insulin resistancepostmenopausesex hormone-binding globulintestosterone (tt)type 2 diabetes mellitus (dm)

Identifiers

PMID41089103
PMCPMC12515588

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.