ArticleArthritis care & research2026
Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease.
Article in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveAntinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non-AI conditions is associated with disease.
methodsWe conducted a retrospective case-control study in the Vanderbilt University Medical Center's de-identified electronic medical record system. Individuals without AI disease who had an ANA test were classified into three groups: high titer (HT; ANA ≥ 1:640), low titer (LT; ANA ≤ 1:80), and negative (NG) ANA results. The prevalence of diagnoses recorded within 90 days of the ANA test were compared among groups in a phenome-wide association study adjusting for age at ANA testing, sex, median body mass index (BMI), and reported race. A P value <5 × 10
resultsA total of 28,781 individuals qualified for the study: 3.1% in the HT, 12.3% in the LT, and 84.6% in the NG groups. BMI was similar among groups (P value = 0.345), but individuals in the HT group were older (P = 3.9 × 10
conclusionA high ANA titer in the absence of an AI disease was associated with increased risk of liver disorders and related risk factors and complications.
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