Evidence map›Paper›PMID 41088938›Full record

ArticleCurrent neuropharmacology2026

Delivery of Nerve Growth Factor via Exosome Attenuates Neuropathic Pain in a Rat Model of Chronic Constriction Injury.

Yangyi Li, Chengbo Chen, Changsheng Su, Shunyuan Li, Zhibin Wen, Yifan Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Clinical Applications of Extracellular Vesicles: Promises and Pitfalls.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yangyi LiDepartment of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 1028 South of Anji Road, Quanzhou, 362000, Fujian, China.
Chengbo ChenDepartment of Cardiology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 1028 South of Anji Road, Quanzhou, 362000, Fujian, China.
Changsheng SuDepartment of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 1028 South of Anji Road, Quanzhou, 362000, Fujian, China.
Shunyuan LiDepartment of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 1028 South of Anji Road, Quanzhou, 362000, Fujian, China.
Zhibin WenDepartment of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 1028 South of Anji Road, Quanzhou, 362000, Fujian, China.
Yifan ZhengDepartment of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 1028 South of Anji Road, Quanzhou, 362000, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe nerve growth factor (NGF) is a crucial neurotrophic factor with the ability to induce neuronal differentiation. However, whether NGF-loaded exosomes (Exo-NGF) can alleviate neuropathic pain in chronic constriction injury (CCI) rats remains unclear.

methodsA neuropathic pain model was established using CCI rats. The pain was assessed using the von Frey test and the hot plate test. Exo-NGF was collected from HEK293 cells transfected with an NGF plasmid. The diameter of Exo-NGF was determined using transmission electron microscopy. Protein levels of inflammatory factors, including IL-18, IL-1β, and TNF-α, were measured using enzyme- linked immunosorbent assay, and their mRNA levels were evaluated using qPCR. The NODlike receptor family pyrin domain-containing protein 3 (NLRP3) protein levels were determined using immunostaining and Western blot.

resultsNGF protein and mRNA were highly expressed in Exo-NGF. The mRNA in Exo-NGF was successfully delivered into neural stem cells and promoted their differentiation. Injection of Exo- NGF into the spinal dorsal horn significantly alleviated mechanical allodynia and thermal hyperalgesia. Additionally, Exo-NGF reduced levels of IL-18, IL-1β, and TNF-α. NLRP3 and its key components, including apoptosis-associated speck-like protein and caspase-1, were also reduced by Exo- NGF treatment in CCI rats. DISCUSSION: Our findings highlight the therapeutic potential of exosome-based NGF delivery for treating chronic pain conditions.

conclusionExo-NGF significantly alleviates neuropathic pain by suppressing inflammation and NLRP3 activation.

Indexed as

ExosomesNerve Growth FactorNeuralgiaAnimalsDisease Models, AnimalHEK293 CellsHumansHyperalgesiaMaleNLR Family, Pyrin Domain-Containing 3 ProteinRatsRats, Sprague-DawleyNerve Growth FactorNgf protein, ratNLR Family, Pyrin Domain-Containing 3 ProteinCCI ratsexosomeinflammationNeuropathic painneurotrophic factorprotein levelsvon Frey test

Identifiers

PMID41088938
PMCPMC13269910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.