Evidence map›Paper›PMID 41088934›Full record

ArticleCurrent medicinal chemistry2026

Side Chain Effects on the Lipophilicity-antimicrobial-toxicity Correlation of Greener 4-Alkoxy/Amino-7-Chloroquinolines.

Gabriela F Fiss, Everton P Silva, Maria F S Madruga, Abraao P Sousa, Helivaldo D S Souza, Radamis B Castor, Maria H Nascimento, Krystyna G Lira, Petronio F Athayde-Filho

Abstract read
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In one paragraph

Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriela F FissLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0001-8156-2272
Everton P SilvaLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0009-0003-8513-316X
Maria F S MadrugaLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0002-7518-0742
Abraao P SousaLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0009-0005-6585-2866
Helivaldo D S SouzaLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0002-1708-4066
Radamis B CastorDepartment of Molecular Biology, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0001-6665-8786
Maria H NascimentoDepartment of Molecular Biology, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0002-8385-6810
Krystyna G LiraDepartment of Molecular Biology, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0002-7892-2705
Petronio F Athayde-FilhoLaboratório de Pesquisa em Bioenergia e Síntese Orgânica (LPBS), Department of Chemistry, Federal University of Paraíba, João Pessoa, Brazil.ORCID 0000-0003-0982-8261

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 403134/2021-8
6 · The paper itself

Abstract

backgroundMore robust 4-substituted 7-chloroquinolines have been investigated for their diverse properties. However, there is still no systematic study that correlates the effects of the side chain at the 4-position of chloroquine and hydroxychloroquine derivatives with their lipophilicity, antimicrobial and toxicity properties.

objectiveTo this end, a cleaner and facile approach was planned to obtain nineteen 4- substituted 7-chloroquinolines, whose influence of the substituent group and side chain extension at the 4-position on their properties was studied.

methods4-Alkoxy/amino-7-chloroquinolines were prepared by a nucleophilic aromatic substitution (SNAr) reaction between 4,7-dichloroquinoline and alcohols/amines, evaluated for their

results4-Alkoxy/amino-7-chloroquinolines were obtained in yields ranging from 81 to 100%. The best results showed antimicrobial activity against Pseudomonas aeruginosa for 4-amino-7-chloroquinolines 6-8, with halos greater than 20 mm, and against C. albicans for 4-amino-7-chloroquinolines 1-3, with halos close to 30 mm. A correspondence between Minnow toxicity prediction and

conclusionConsidering the results for compounds 1-3 and 6-8 with greater activity against

Indexed as

Anti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsQuinolinesAnimalsArtemiaCandida albicansGram-Negative BacteriaGram-Positive BacteriaHydrophobic and Hydrophilic InteractionsLarvaMicrobial Sensitivity TestsMolecular StructurePseudomonas aeruginosaStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsQuinolines7-chloroquinolinesAntibioticsArtemia salinadrug researchfungicidesgreen chemistry.

Identifiers

PMID41088934
PMCPMC13223418

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.