Evidence map›Paper›PMID 41088931›Full record

ArticleCurrent molecular medicine2026

SIRT6 Relieves Acute Lung Injury by Enhancing PGC-1α Expression and Improving Mitochondrial Function.

Xiangyun Li, Yanshuai Mo, Jia Shi, Shasha Liu, Shasha Bu, Huayang Liu, Wenxing Li, Jianbo Yu

Abstract read
PubMed Publisher
In one paragraph

Article in Current molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiangyun LiDepartment of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Changjiang street, Nankai district, Tianjin 300000, China.
Yanshuai MoDepartment of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Changjiang street, Nankai district, Tianjin 300000, China.
Jia ShiDepartment of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Changjiang street, Nankai district, Tianjin 300000, China.
Shasha LiuDepartment of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Changjiang street, Nankai district, Tianjin 300000, China.
Shasha BuCharacteristic Medical Center of the Chinese people's Armed Police Force, Tianjin Medical University, 300070, Tianjin, China.
Huayang LiuDepartment of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Changjiang street, Nankai district, Tianjin 300000, China.
Wenxing LiDepartment of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Changjiang street, Nankai district, Tianjin 300000, China.
Jianbo YuDepartment of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Changjiang street, Nankai district, Tianjin 300000, China.

Funding

National Natural Science Foundation of China 82074153Tianjin Key Medical Discipline Construction Project TJYXZDXK-3-013BYoung Elite Scientists Sponsorship Program by CAST 2022QNRC001Youth Fund of the National Natural Science Foundation of China 82004076, 82102247
6 · The paper itself

Abstract

introductionSepsis-induced acute lung injury (ALI) is closely related to the dysfunction of mitochondria. Sirtuin 6 (SIRT6), as a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacylase, is involved in several cellular processes. However, research has shown that the interaction of SIRT6 and mitochondrial function plays a role in acute lung injury. The objective of this research study was to explore the effect of SIRT6 on mitochondrial function during septic lung injury.

methodsLipopolysaccharide (LPS) was used to establish ALI models in C57BL/6J, SIRT6

conclusionSIRT6 protected against LPS-induced acute lung injury by promoting PGC-1α expression and improving mitochondrial function both

Indexed as

Acute Lung InjuryMitochondriaPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSirtuinsAnimalsCell LineDisease Models, AnimalGene Expression RegulationLipopolysaccharidesMaleMiceMice, Inbred C57BLLipopolysaccharidesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSirt6 protein, mouseSirtuinsAcute lung injurygamma coactivator-1αmitochondrial dysfunctionperoxisome proliferator-activated receptorsirtuin 6

Identifiers

PMID41088931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.