Evidence map›Paper›PMID 41088842›Full record

ArticleFEBS letters2026

4-nitrobenzoate inhibits 4-hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy.

Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ignasi Bofill VerdaguerDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Brazil.ORCID 0000-0002-5625-5454
Matheus Felipe SantosDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Maurício Mazzine FilhoDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Gabriela Oliveira CastroDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Agustín HernándezBetternostics S.L., Noain, Navarre, Spain.
Manoel Aparecido PeresDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
Alejandro Miguel KatzinDepartment of Parasitology, Institute of Biomedical Sciences, University of São Paulo, Brazil.ORCID 0000-0002-4782-2162
Marcell CrispimDepartment of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, Federal University of Alfenas, Brazil.ORCID 0000-0002-2856-5471

Funding

Fundação de Amparo Pesquisa do Estado de São Paulo 2017/224521Fundação de Amparo Pesquisa do Estado de São Paulo 2022/095264Fundação de Amparo Pesquisa do Estado de São Paulo 2023/123431Fundação de Amparo Pesquisa do Estado de São Paulo 2024/099972
6 · The paper itself

Abstract

Ubiquinone (UQ) is essential for the electron transport chain in Plasmodium falciparum, the causative agent of severe malaria. Its biosynthesis begins with the condensation of 4-hydroxybenzoate (4-HB) and an isoprenoid chain, catalyzed by 4-HB polyprenyltransferase (4-HPT; COQ2 gene). Atovaquone (AV) inhibits the mitochondrial bc1 complex by competing with ubiquinol (UQH

Indexed as

Alkyl and Aryl TransferasesAntimalarialsAtovaquoneMalariaParabensPlasmodium falciparumProtozoan ProteinsAnimalsDrug SynergismMicePlasmodium bergheiProguanilSaccharomyces cerevisiaeUbiquinone4-hydroxybenzoic acidAlkyl and Aryl TransferasesAntimalarialsAtovaquoneParabensProguanilProtozoan ProteinsUbiquinone4‐hydroxybenzoate4‐hydroxybenzoate polyprenyltransferase4‐nitrobenzoateatovaquoneCOQ2malariaPlasmodium falciparumubiquinone

Identifiers

PMID41088842
PMCPMC12834005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.