Evidence map›Paper›PMID 41088770›Full record

ArticleProtein science : a publication of the Protein Society2025

Amino acid substitutions at rheostat positions in the Na

Liskin Swint-Kruse, Melissa J Ruggiero, Bruno Hagenbuch

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Amino acid substitutions at rheostat positions in the NaProtein science : a publication of the Protein Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Liskin Swint-KruseDepartment of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-5925-9741
Melissa J RuggieroDepartment of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA.
Bruno HagenbuchDepartment of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0002-2938-8630

Funding

Molecular Characterization of Hepatic Organic Anion Transporting PolypeptidesR01GM077336 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI HAGENBUCH, BRUNO · 2007 to 2019
$3.7M
Using dynamic network models to quantitatively predict changes in binding affinity/specificity that arise from long-range amino acid substitutionsR01GM147635 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI OZKAN, SEFIKA BANU, SWINT-KRUSE, LISKIN · 2022 to 2025
$1.8M
Post-translational regulation of hepatic uptake transporters in health and diseaseR01GM149665 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BRUNO HAGENBUCH · 2024 to 2026
$1.2M
NIGMS NIH HHS R01 GM077336NIGMS NIH HHS R01 GM147635NIGMS NIH HHS R01 GM149665NIH HHS GM077336NIH HHS GM147635NIH HHS GM149665W. M. Keck Foundation
6 · The paper itself

Abstract

In the human Na

Indexed as

Amino Acid SubstitutionOrganic Anion Transporters, Sodium-DependentSymportersHEK293 CellsHumansOrganic Anion Transporters, Sodium-Dependentsodium-bile acid cotransporterSymportersNa+/taurocholate cotransporting polypeptidesite‐directed mutagenesistransporter function and expression

Identifiers

PMID41088770
PMCPMC12521614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.