Evidence map›Paper›PMID 41088570›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.

Zhong-Yue Liu, Yu-Wen Qian, Ji-Mei Gu, Xiao-Ping Shao, Meng-Yuan Miao, Jie-Qiong Lyu, Zhong-Xiao Wan, Li-Qiang Qin, Qi Fang, Guo-Chong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhong-Yue LiuDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.ORCID 0009-0007-8909-6633
Yu-Wen QianDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.
Ji-Mei GuDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.
Xiao-Ping ShaoDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.
Meng-Yuan MiaoDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.
Jie-Qiong LyuDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.
Zhong-Xiao WanDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.
Li-Qiang QinDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.
Qi FangDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.
Guo-Chong ChenDepartment of Neurology, The Fourth Affiliated Hospital (Medical Center of Soochow University), School of Public Health, Suzhou Medical College, Soochow University, Suzhou, China.

Funding

Gusu Leading Talent Plan for Scientific and Technological Innovation and Entrepreneurship ZXL2023345Priority Academic Program Development of Jiangsu Higher Education Institutions
6 · The paper itself

Abstract

backgroundThe relationship between regional adiposity and dementia remains poorly understood.

methodsThis study included 440 861 UK Biobank participants initially free of dementia, stroke and cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia across quartiles of waist circumference (WC) or hip circumference (HC) were calculated, after multivariable adjustment with mutual adjustment for WC and HC. The potential mediating roles of 21 biomarkers covering distinct metabolic pathways were assessed. In a subsample with body composition quantified by dual-energy X-ray absorptiometry, the associations of android and gynoid fatness with magnetic resonance imaging-derived volumetric brain measures were further assessed.

resultsOver a median follow-up of 12.7 years, there were 2899 incident cases of dementia in females and 3306 cases in males. After multivariable adjustment, WC was positively associated with the risk of dementia (predominantly vascular dementia) in both sexes, but the associations disappeared after further adjusting for the treatments for metabolic disorders. HC was inversely associated with dementia both in females (HR

conclusionsAndroid and gynoid adipose tissues may exert divergent influences on the development of dementia, with evidence for shared and distinct mechanisms between sexes.

Indexed as

AdiposityBrainDementiaAgedFemaleHumansIncidenceMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsWaist Circumferenceadiposityandroid fatbrain MRIdementiagynoid fat

Identifiers

PMID41088570
PMCPMC12521049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.